Detalhe da pesquisa
1.
LAG3 ectodomain structure reveals functional interfaces for ligand and antibody recognition.
Nat Immunol
; 23(7): 1031-1041, 2022 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-35761082
2.
Multivalent Small-Molecule Pan-RAS Inhibitors.
Cell
; 168(5): 878-889.e29, 2017 02 23.
Artigo
em Inglês
| MEDLINE | ID: mdl-28235199
3.
Machine learning-driven multiscale modeling reveals lipid-dependent dynamics of RAS signaling proteins.
Proc Natl Acad Sci U S A
; 119(1)2022 01 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-34983849
4.
Uncovering a membrane-distal conformation of KRAS available to recruit RAF to the plasma membrane.
Proc Natl Acad Sci U S A
; 117(39): 24258-24268, 2020 09 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-32913056
5.
Exploring CRD mobility during RAS/RAF engagement at the membrane.
Biophys J
; 121(19): 3630-3650, 2022 10 04.
Artigo
em Inglês
| MEDLINE | ID: mdl-35778842
6.
KRAS G13D sensitivity to neurofibromin-mediated GTP hydrolysis.
Proc Natl Acad Sci U S A
; 116(44): 22122-22131, 2019 10 29.
Artigo
em Inglês
| MEDLINE | ID: mdl-31611389
7.
Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.
Nature
; 518(7537): 120-4, 2015 Feb 05.
Artigo
em Inglês
| MEDLINE | ID: mdl-25383525
8.
KRAS Prenylation Is Required for Bivalent Binding with Calmodulin in a Nucleotide-Independent Manner.
Biophys J
; 116(6): 1049-1063, 2019 03 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-30846362
9.
Structural basis of recognition of farnesylated and methylated KRAS4b by PDEδ.
Proc Natl Acad Sci U S A
; 113(44): E6766-E6775, 2016 11 01.
Artigo
em Inglês
| MEDLINE | ID: mdl-27791178
10.
Insulin Hexamer-Caged Gadolinium Ion as MRI Contrast-o-phore.
Chemistry
; 24(42): 10646-10652, 2018 Jul 25.
Artigo
em Inglês
| MEDLINE | ID: mdl-29873848
11.
The small molecule BI-2852 induces a nonfunctional dimer of KRAS.
Proc Natl Acad Sci U S A
; 117(7): 3363-3364, 2020 02 18.
Artigo
em Inglês
| MEDLINE | ID: mdl-32047043
12.
Discovery of New Classes of Compounds that Reactivate Acetylcholinesterase Inhibited by Organophosphates.
Chembiochem
; 16(15): 2205-2215, 2015 Oct 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-26350723
13.
Comparative analysis of KRAS4a and KRAS4b splice variants reveals distinctive structural and functional properties.
Sci Adv
; 10(7): eadj4137, 2024 Feb 16.
Artigo
em Inglês
| MEDLINE | ID: mdl-38354232
14.
Use of phage display biopanning as a tool to design CAR-T cells against glioma stem cells.
Front Oncol
; 13: 1124272, 2023.
Artigo
em Inglês
| MEDLINE | ID: mdl-37035164
15.
Reduced dynamic complexity allows structure elucidation of an excited state of KRASG13D.
Commun Biol
; 6(1): 594, 2023 06 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37268708
16.
Allosteric Regulation of Switch-II Domain Controls KRAS Oncogenicity.
Cancer Res
; 83(19): 3176-3183, 2023 10 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-37556505
17.
Asynchronous Reciprocal Coupling of Martini 2.2 Coarse-Grained and CHARMM36 All-Atom Simulations in an Automated Multiscale Framework.
J Chem Theory Comput
; 18(8): 5025-5045, 2022 Aug 09.
Artigo
em Inglês
| MEDLINE | ID: mdl-35866871
18.
The crystal structure of Streptococcus pyogenes uridine phosphorylase reveals a distinct subfamily of nucleoside phosphorylases.
Biochemistry
; 50(30): 6549-58, 2011 Aug 02.
Artigo
em Inglês
| MEDLINE | ID: mdl-21707079
19.
A novel mechanism of sulfur transfer catalyzed by O-acetylhomoserine sulfhydrylase in the methionine-biosynthetic pathway of Wolinella succinogenes.
Acta Crystallogr D Biol Crystallogr
; 67(Pt 10): 831-8, 2011 Oct.
Artigo
em Inglês
| MEDLINE | ID: mdl-21931214
20.
KRAS interaction with RAF1 RAS-binding domain and cysteine-rich domain provides insights into RAS-mediated RAF activation.
Nat Commun
; 12(1): 1176, 2021 02 19.
Artigo
em Inglês
| MEDLINE | ID: mdl-33608534